Materials and Methods: Emulgel formulations of diclofenac potassium were prepared using different . subjected to various evaluation parameters such as drug. Emulgels have been extensively covered as a promising drug delivery system for the administration of lipophilic drugs. This work was. Formulation and Evaluation of Luliconazole Emulgel for. Topical Drug Delivery. Dhobale Shankar,* Shelke Gajanan, Jadhav Suresh, Gaikwad.
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These results were concordant with the study conducted by Fathalla et al.
Similar Articles in this Journal. Group Evxluation was diseased control, group II received dose of 25 mg of aceclofenac emulgel whereas group III received marketed diclofenac emulgel. In-vitro and in-vivo evaluation of niosomal gel containing aceclofenac for sustained drug delivery. Commercially available Terbinafine hydrochloride cream was used for comparison. In both the models, animals treated with aceclofenac emulgel showed inflammation reversal in 2 h of application, resulting in improved inhibition of inflammation with an effect lasting up to 6 h.
The influence of the type of gelling agent and the concentration of both the oil phase and emulsifying agent on the release of the drug and its microbial activity were investigate using 2 3 factorial design in addition, rheological properties were also evaluated.
Thus, the formulated emulgel was considered optimum, based on the pharmaceutical characteristics and further subjected to animal testing for anti-inflammatory activity using two animal models viz.
Moreover, the reduction in inflammation was comparable to that of the most consumer preferred anti-inflammatory emulgel brand of diclofenac.
Formulation and evaluation of Cyclosporin A emulgel for ocular delivery.
Formulation and evaluation of mefenamic acid emulgel for topical delivery. Formulation and evaluation of oxiconazole emulgel for topical drug delivery Author: Group II received aceclofenac emulgel equivalent to 2. A novel approach for enhancing topical delivery of aceclofenac.
In this regard, the study provides a preliminary comparative efficacy data for both the drugs, providing a foundation for a robust clinical evaluation in future studies. Versions Version 1 All other chemicals and solvents were of analytical reagent grade.
FORMULATION AND EVALUATION OF CLINDAMYCIN PHOSPHATE EMULGEL
Percentage inflammation was calculated as under:. An emergent evaluatiom in topical drug delivery. The micro emulsion formulation developed in this maneuver was found to be satisfactory in terms of physical characteristics like clarity, particle size as well and in vitro drug diffusion Fig.
Formulation, development and evaluation of emulgel: Testing for the drug release from the micro emulsion itself is critical prior to designing an emulgel.
FORMULATION AND EVALUATION OF TERBINAFINE HYDROCHLORIDE FILM FORMING EMULGEL
Terbinafine hydrochloride, CarbapolAntifungal activity, Film formation, Emulgel formulation. Aceclofenac was added to it in small parts until the drug completely dissolved in the solution. The resultant microemulsion and emulgel both exhibited the desired drug release in-vitro and firmulation. Most read articles by the same author s S. The particle size of the microemulsion was found to be The total duration of this study was approximately 5 months considering conceptualization to completion of animal studies.
In another study by Shah et al.
Voltaren emulgel produced maximum inhibition of The percentage change in inflammation was calculated by the same formula as mentioned above. The developed emulgels were evaluated for their physicochemical properties like color, homogeneity, consistency, spreadability, pH value, rheological behavior, drug content, drug release formmulation stability.
Secondly, relevance of this fact is even more when the respective drugs are taken life-long in chronic conditions like arthritis. Emulyel 12, DOI: The dual novel technique viz.
In this study, polymer-based emulgel formulation of aceclofenac with a microemulsion base was developed and assessed for its anti-inflammatory activity. Anti-inflammatory studies by croton oil induced ear edema: Topical drug administration is simplest and easiest route of localized drug delivery anywhere in the body by routes as ophthalmic, rectal, vaginal and skin. A total of 6 rats were used in each group, for placebo, marketed gel and aceclofenac formulated emulgel, amounting to 18 rats in total.
The aim of present study was to develop an emulgel formulation of clindamycin phosphate using Carbopol or HPMC as a gelling agent. Aceclofenac formuoation a better tolerability profile compared to diclofenac when taken orally.